https://geonika.agis.uniba.sk/tsenz/index.php?action=history&feed=atom&title=Tolerance 2026-04-08T00:20:01Z História úprav pre túto stránku na wiki MediaWiki 1.31.1 https://geonika.agis.uniba.sk/tsenz/index.php?title=Tolerance&diff=334&oldid=prev 2014-08-13T08:33:07Z

<p>‎<span dir="auto"><span class="autocomment">References</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="sk"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Staršia verzia</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Verzia zo dňa a času 08:33, 13. august 2014</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l24" >Riadok 24:</td> <td colspan="2" class="diff-lineno">Riadok 24:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* WHO (2009) <del class="diffchange diffchange-inline">[</del>Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence<del class="diffchange diffchange-inline">]</del></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* WHO (2009) Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Links==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Links==</div></td></tr> </table>

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<p>Importing text file</p> <p><b>Nová stránka</b></p><div>:Slovak term: [[Slovenský termín]]<br /> # A decrease in response to a drug dose that occurs with continued use (WHO 2009).<br /> <br /> ==Explanation==<br /> If an individual is tolerant to a drug, increased doses are required to achieve the effects<br /> originally produced by lower doses. Both physiological and psychosocial factors may<br /> contribute to the development of tolerance (WHO 2009).<br /> <br /> Tolerance is one of the criteria of dependence syndrome (WHO 2009).<br /> <br /> ==Example==<br /> Physiological factors include metabolic and functional tolerance. In metabolic tolerance, the<br /> body can eliminate the substance more readily, because the substance is metabolized at an<br /> increased rate. In functional tolerance, the central nervous system is less sensitive to the<br /> substance. An example of a psychosocial factor contributing to tolerance is behavioural<br /> tolerance, where learning or altered environmental constraints change the affect of the<br /> drug.<br /> <br /> Acute tolerance refers to rapid, temporary accommodation to the effect of a substance<br /> following a single dose.<br /> <br /> Reverse tolerance, also known as sensitization, refers to a condition where the response<br /> to a substance increases with repeated use (WHO 2009).<br /> <br /> ==References==<br /> * WHO (2009) [Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence]<br /> <br /> ==Links==<br /> * [http://apps.who.int/thelexicon/ WHO — The Health and Environment Lexicon]<br /> <br /> [[Category:EN]]</div>

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