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:Slovak term: [[Slovenský termín]]
# Estimated maximum amount of an agent, expressed on a body mass basis, to which individuals in a (sub)population may be exposed daily over their lifetimes without appreciable health risk (WHO 2004).

Acronym: TDI

==Explanation==
The TDI is an estimate of the amount of a substance in food and drinking-water, expressed
on a body weight basis (mg/kg or mg/kg of body weight), that can be ingested over a
lifetime without appreciable health risk (WHO 2006).

It should be noted that the terms [[ADI]] and TDI are used in different context and are not
synonymous.

==Example==
As it relates to administration in drinking-water, for chemicals that give rise to such toxic
effects, a tolerable daily intake should be derived as follows, using the most sensitive
end-point in the most relevant study (WHO 2006):

TDI =(NOAEL or LOAEL) / UF

where:
* NOAEL = no-observed-adverse-effect level
* LOAEL = lowest-observed-adverse-effect level
* UF = uncertainty factor

==References==
* WHO (2006) [http://www.who.int/water_sanitation_health/dwq/gdwq0506.pdf Guidelines for Drinking-water Quality, First Addendum to Third Edition, Volume 1, Recommendations].
* WHO (2004) [http://www.who.int/ipcs/methods/harmonization/areas/ipcsterminologyparts1and2.pdf IPCS Risk assessment terminology: Internationally harmonized terms in relation to chemicals, Geneva].

==Links==
* [http://apps.who.int/thelexicon/ WHO — The Health and Environment Lexicon]
* [WHO Guidelines for Drinking-water Quality]

[[Category:EN]]

Tolerable daily intake - História úprav

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